4DB Center: Physics of Metastasis over Time and Space

Dr. Levy is the Director of Human Genomics at JCVI where he co-leads the Human Genomic Medicine group with Dr Robert Strausberg. Dr Levy has extensive experience in genomics, genetics and computational biology and currently leads a Re-sequencing and Genotyping Center contract from the National Heart, Lung and Blood Institute, providing targeted DNA sequencing of the human clinical samples for multiple investigators. Since its inception in October 2004, NHLBI Resequencing Center at JCVI has collaborated with over 14 distinct research teams working on over 2,700 human samples representing diverse human disease phenotypes. The re-sequencing team led by Dr Levy has produced over 300mb of “finished” human sequence, detecting variant genotypes within targeted gene regions, providing over three million genotype calls inclusive of SNP and insertion/deletion polymorphisms. Dr Levy has also spearheaded efforts to employ second generation sequencing technologies (454, Illumina and SOLiD) for targeted sequencing in human samples and has conducted extensive studies aimed at understanding their strengths and limitations. Dr Levy co-directed a multidisciplinary team that recently identified novel gene fusions in breast cancer cell lines. Dr Levy brings extensive hands-on experience in genomics and computational biology to the current proposal as well as his tested abilities in large-scale project management. Dr. Levy will direct the efforts of Research Project 3, coordinating the amplification efforts of Dr Lasken’s group, directing the targeted gene and RNA sequencing and data analysis in coordination with Dr Nicholas Schork’s group at Scripps Genomic Medicine.